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Description:AML, histone deacetylase inhibitor, fludarabine Introduction Histone deacetylase inhibitors HDACIs consist of a group of agents that modify chromatin structure and, by extension, gene expression [ 1 ] and kill transformed cells through diverse mechanisms, including induction of oxidative DNA damage, up-regulation of death receptors, disruption of chaperone proteins, and interference with DNA repair, among numerous others [ 2 - 4 ]. After incubation with the corresponding primary and secondary antibodies, blots were developed by enhanced chemiluminesence New England Nuclear; Boston, MA. Primary antibodies were as follows: After an additional interval generally 24 hrs , cells were processed and assayed as previously described in detail [ 15 ].

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Views: 4537 Date: 2018-08-29 Favorited: 34 favorites

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